Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology

Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology

Blog Article

The pancreatic acinar cell is a classical model for studies of secretion and signal transduction mechanisms.Because of the extensive endoplasmic reticulum and the large granular compartment, it nightstick twm-850xl has been possible - by direct measurements - to obtain considerable insights into intracellular Ca2+ handling under both normal and pathological conditions.Recent studies have also revealed important characteristics of stimulus-secretion coupling mechanisms in isolated human pancreatic acinar cells.The acinar cells are potentially dangerous because of the high intra-granular concentration of proteases, which become inappropriately activated in the human disease acute pancreatitis.

This disease is due to toxic Ca2+ signals generated by excessive liberation of Ca2+ from both hockey puck dab rig the endoplasmic reticulum and the secretory granules.